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The first enrollment period for the Affordable Care Act ends at midnight Monday, closing one chapter on President Obama’s landmark health-care law and paving the way for a new round of confrontations that could ultimately determine the law’s long-term prospects.

Supporters face an array of political, financial and legal challenges in the coming months. Democrats and insurance industry officials are already seeking ways to blunt what may be the next big controversy: an expected increase in monthly insurance premiums next year for the health plans sold through the federal and state marketplaces.

Republicans, meanwhile, continue to use the law to attack vulnerable Democratic incumbents in the midterm elections, which will decide whether the GOP wins control of the Senate.

Combatants on both sides debated the administration’s report last week that 6 million people had signed up for private plans. “The law’s working,” White House senior adviser David Plouffe said on ABC’s “This Week.” He added: “And this was a seminal achievement.”

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