In the most significant change to U.S. cigarette packs in 25 years, the Food and Drug Administration on Tuesday released nine new warning labels that depict in graphic detail the negative health effects of tobacco use.

Among the images to appear on cigarette packs are rotting and diseased teeth and gums and a man with a tracheotomy smoking.

Also included among the labels are: the corpse of a smoker, diseased lungs, and a mother holding her baby with smoke swirling around them. They include phrases like “Smoking can kill you” and “Cigarettes cause cancer” and feature graphic images to convey the dangers of tobacco, which is responsible for about 443,000 deaths in the U.S. a year.

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